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Beilstein J. Org. Chem. 2018, 14, 2607–2617, doi:10.3762/bjoc.14.239
Graphical Abstract
Figure 1: Mannosides as inhibitors of the lectin FimH from uropathogenic Escherichia coli.
Figure 2: Galactosides targeting uropathogenic Escherichia coli FmlH (compounds 8 and 9) and Pseudomonas aeru...
Figure 3: Mannosides and fucosides as inhibitors of P. aeruginosa LecB.
Figure 4: β-Cyclodextrin-based antitoxin 19 against S. aureus α-hemolysin and the decavalent Shiga toxin inhi...
Figure 5: The mechanism of quorum sensing and representative signaling molecules.
Figure 6: Inhibitors of bacterial quorum sensing.
Beilstein J. Org. Chem. 2017, 13, 2631–2636, doi:10.3762/bjoc.13.261
Figure 1: AnhydroMurNAc and derivatives.
Scheme 1: Our approach to AnhydroMurNAc compared with literature preparations.
Scheme 2: Synthesis of AnhydroMurNAc. Conditions: (a) (±)-2-chloropropionic acid, NaH, dioxane, 45 °C to 90 °...
Figure 2: 2D NMR correlations confirming the structure of 12.
Scheme 3: Synthesis of AnhydroMurNAc and diastereomer 5. Conditions: (a) (±)-2-chloropropionic acid, NaH, dio...